Kidney cancer

Kidney cancer is a relatively rare form of cancer that starts in the cells of the kidney. When you or someone close to you has been diagnosed with kidney cancer, it can feel overwhelming. Cancer Council Queensland is here to help you understand the condition and help equip you with information, so you don’t have to go through kidney cancer alone.

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About kidney cancer

In Queensland, around 800 people are diagnosed with kidney cancer each year. Across Australia, that number is around 4,500 people.

While this may seem like a high number, it makes up only about 2.5% of all cancers, affecting one in 65 by the age of 85. Most of those diagnosed are aged 50–65. Kidney cancer is Australian’s seventh most common cancer.

The most common type of kidney cancer, called renal cell carcinoma (RCC) or adenocarcinoma, begins in the kidney tissue and accounts for about 90% of diagnoses. Generally, a cancerous tumour on the kidney develops in one kidney although, in rare cases, both kidneys can be affected.

When doctors talk about cancer in the kidney, they categorise it as either localised (confined to the kidney) or advanced (spread beyond it). Most localised cases involve only one tumour, but sometimes tumours may multiply within the same area.

If the tumour grows, it may advance (or metastasise) and spread to nearby sites, such as surrounding fatty tissue, veins, adrenal glands, lymph nodes, ureters, or liver. A kidney tumour may also be classed as a secondary cancer, meaning it has started elsewhere in the body and made its way to the kidneys. This is rare and requires a different treatment approach.

Risk Factors

The exact cause of kidney cancer is an ongoing area of research. What we do know is that certain factors may increase someone’s risk.

Risk factors include:

  • Smoking: With up to one in three of all kidney cancers thought to be linked to smoking, people who smoke can nearly double their risk of developing cancer than non-smokers.
  • Excess body weight: Increased body fat may affect certain hormone levels, which could increase your risk of kidney cancer.
  • High blood pressure: Over time, prolonged high blood pressure increases the risk of developing kidney cancer regardless of the cause.
  • Kidney failure: People managing end-stage kidney disease or needing long-term dialysis may face an increased risk.
  • Family history: Having a parent, brother or sister (first-degree relative) who has experienced kidney cancer can place you at a higher risk.
  • Inherited conditions: About 2–3% of cases are linked to inherited conditions such as von Hippel-Lindau disease, hereditary papillary RCC, Birt-Hogg-Dube syndrome and Lynch Syndrome.
  • Toxic exposure: Regular contact with certain chemicals like metal degreasers, arsenic, or cadmium might raise your risk.

It’s important to remember that having any of these risk factors doesn’t mean you’ll develop kidney cancer. These are just guidelines to help you be aware of any increased risk possibilities and to help you find ways to minimise these if possible.

If you’re worried about any of the above risk factors, you can always chat to your GP or call our Cancer Council Queensland team on 13 11 20. We’re always here to help and support you and your family.

Symptoms of kidney cancer

Many people miss the early warning signs of kidney cancer, and it’s usually only discovered during tests for unrelated conditions. Knowing the potential signs and what to look for can help with early detection, which may improve your prognosis.

Common symptoms include:

  • Blood in urine (haematuria): These changes can be obvious, or your urine might appear dark or rust coloured.
  • Unexplained back pain: This pain can be central, spread throughout the lower back, or it can occur on one side – and it is unrelated to any injury.
  • Noticeable lump in the abdomen: Usually, this will be found in the stomach area. However, any unexplained lump, no matter the location, should always be assessed by your GP.
  • Unusual constant fatigue: Feeling of tiredness that can’t be explained by other factors.
  • Unexplained weight loss: Losing weight without changing your eating or exercise habits.
  • Fever or night sweats: Changes in body temperature not caused by a cold, flu or hormonal changes.

Kidney cancer can impact hormone production, which can lead to various other symptoms, like dizziness, headaches, constipation, abdominal pain, and mood changes. These symptoms occur due to changes in red blood cell count or calcium levels in the blood, which can cause conditions such as anaemia, polycythaemia, or hypercalcaemia.

While it may seem worrying if you experience any of these symptoms, they’re often related to less serious conditions like muscle strains and urinary tract infections. It’s natural to feel concerned, though, and important to rule out more serious conditions, so make an appointment with your GP as soon as possible.

Diagnosis

Kidney tumours are often discovered unexpectedly during scans or tests for other unrelated concerns. If your doctor has any concerns, they’ll recommend some tests to understand better what is happening with your health.

The most common diagnostic tests include urine and blood analysis. While these can’t diagnose kidney cancer, they can help assess your overall wellbeing and kidney health and indicate whether further testing is necessary.

Advanced diagnostic tools

If your doctor wants to explore in-depth, they may suggest other advanced testing methods, such as imaging scans, to give a more detailed view of your kidneys and the surrounding tissues.

You may have one or more of the following scans:

  • Ultrasound: Creates imagery using sound waves. It is usually gentle, painless, and noninvasive. However, in some cases, the doctor may require an internal examination of the bladder, ureters, and kidneys.
  • CT scan: Uses X-rays to take detailed cross-sectional imagery.
  • MRI scan: Uses magnetic and radio wave technology for comprehensive internal viewing.
  • Radioisotope bone scan: Mainly used to assess whether the cancer has spread to, and affected, the bones.
  • PET Scan (positron emission tomography): A specialised test using a small amount of radioactive ink to highlight cancer cells. This test is not always suitable for kidney cancer, so it’s not commonly used.

Your doctor may also suggest a biopsy, which is a common procedure, involving taking a small tissue sample for testing. You may not need this, though, because modern imagery scans are often enough to diagnose cancerous kidney tumours. Some tests may need to be repeated to confirm a diagnosis, or during or after receiving cancer treatment, to gauge your progress.

Surgery is often the primary cancer treatment and, if this is the case, the removed tumour may be tested to confirm whether it is cancer.

Any suspected cancer diagnosis is a challenging time, and your healthcare team will guide you through each step with care and understanding. We understand that waiting for test results can be stressful but remember you’re not alone. Don’t hesitate to reach out and talk to a loved one, friend, healthcare professional, or our Cancer Council Queensland team on 13 11 20. You don’t need to wait for a diagnosis to reach out for support.

Treatment

If you’re going through the initial stages of a cancer diagnosis, your healthcare team will create a treatment plan that’s specific to your needs. They’ll consider your overall health and the specifics of your cancer, such as location and whether it has spread.

For most people, surgery offers the most favourable path forward. The procedure is called a nephrectomy, and it usually involves removing all or part of the affected kidney.

If your tumour is under 4cm, you are unwell, or if your age presents a risk, your medical team may suggest careful monitoring (active surveillance) through regular scans instead of immediate surgery, because surgery can have an effect on your body. If your medical team takes this approach, they will monitor your tumour and if they see changes to the nature or growth, they may suggest going ahead with surgery, or other treatment.

Choosing surveillance instead of active treatment might be worrying, but it is sometimes the best course of action, and your medical team will monitor you closely. Don’t hesitate to talk to your doctor if you have any concerns.

Other treatment options

Treatments other than surgery include:

  • Radiofrequency ablation: A treatment that uses radio waves to heat and destroy cancer cells.
  • Stereotactic body radiation therapy (SBRT): Uses X-rays or gamma rays to inhibit the growth of cancer cells and, in some cases, it can also be helpful for pain management.
  • Medication methods: Various medications can help stop or slow down cancer growth. Most cancer medications can cause some side effects, so your doctor will consider the impact on your body and kidneys when deciding what to recommend. These drugs include Immunotherapy (targeting the immune system) and Anti-angiogenics (blocks the blood supply to the tumour).

Feeling confident and having peace of mind while undergoing treatment can be helpful to your healing. Your doctor and healthcare team are there to help and ensure you understand and feel comfortable with any decision.

Prognosis

When we talk about prognosis, we’re talking about the likely or expected outcome of the disease, although it’s important to remember that not even an expert can predict the exact way a disease will progress.

Your doctor can give you their professional opinion on the likely outcome, treatment options and common issues that may arise if you’re diagnosed with kidney cancer.

Early detection can often mean you have more treatment options and a higher chance of successful outcomes, especially if surgery is possible. When advising you on the most suitable care for your situation, your healthcare team will consider your age, overall health and medical history.

If your cancer has spread beyond your kidney, it may not be possible to remove the entire tumour, but there are still plenty of other treatment options available.

Discussing your prognosis and looking ahead can be a very challenging and overwhelming experience. If would like more information or emotional support, contact your healthcare team, family, friends or our Cancer Council Queensland team on 13 11 20.

Questions you may have

What organs does kidney cancer spread to?

In the early stages, cancer in the kidney is typically confined to the affected organ. If it grows, it may spread to nearby organs and structures, such as fatty tissue, veins, adrenal glands, lymph nodes, ureters or the liver. However, in some cases, it can affect distant organs like the lungs, brain, or bones.

Can kidney disease cause cancer?

People living with end-stage kidney disease may have a higher risk of developing cancer. Careful monitoring by your healthcare team is essential in managing this risk. If you are concerned, talk to your doctor.

Are all kidney tumours cancerous?

No, a cancerous tumour on the kidney can be benign (non-cancerous). Benign tumours include small growths called oncocytoma and angiomyolipoma, and may still require treatment like the treatment you may receive for an early kidney cancer diagnosis. Some benign tumours can be significant in size, but they will not spread to other organs but, depending on their location, they may impact the function of nearby structures due to their size.

Is kidney cancer genetic?

About 2–3% of kidney cancers are linked to inherited conditions such as von Hippel–Lindau disease, hereditary papillary RCC, Birt‑Hogg–Dubé syndrome, hereditary leiomyomatosis RCC, tuberous sclerosis, and Lynch syndrome. If you’re concerned about your family history of these conditions, talk to your doctor about your risk.

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